学術論文

学術誌に掲載された論文

Banday AZ, Kaur A, Akagi T, Bhattarai D, Muraoka M, Dev D, Das J, Sachdeva MUS, Karmakar I, Arora K, Kaur G, Pandiarajan V, Jindal AK, Wada T, Koeffler HP, Suri D, Ahluwalia J, Kanegane H, Bhatia P, Rawat A, Singh S.
A Novel CEBPE Variant Causes Severe Infections and Profound Neutropenia.
J Clin Immunol. 2022 Oct;42(7):1434-1450. doi: 10.1007/s10875-022-01304-7.

赤木紀之、黒木青
幹細胞の運命制御機構の解析　－サイトカインLIFによるES細胞の運命制御－
福岡工業大学総合研究機構研究所報　第４号
2021年10月. p67 – p70

Muraoka M, Akagi T*, Ueda A, Wada T, Koeffler HP, Yokota T, Yachie A.
C/EBPε ΔRS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A.
Biochem Biophys Res Commun. 2019;516:293-299.
2019 Aug 13;516(1):293-299. doi: 10.1016/j.bbrc.2019.06.130. Epub 2019 Jun 27.
*Corresponding author.

Kinjo T, Sun C, Ikeda T, Ikegami T, Tada Y, Akagi T, Yokota T, Koide H.
Platelet-derived growth factor-C functions as a growth factor in mouse embryonic stem cells and human fibrosarcoma cells.
Cell Mol Biol Lett. 2018;23:8.
Published: 27 February 2018

Zhu B, Ueda A, Song X, Horike SI, Yokota T, Akagi T*.
Baf53a is involved in survival of mouse ES cells, which can be compensated by Baf53b.
Sci Rep. 2017;7:14059.
2017 Oct 25;7(1):14059. doi: 10.1038/s41598-017-14362-4.
*Corresponding author.

Ueda A, Akagi T*, Yokota T.
GA-binding protein alpha is involved in the survival of mouse embryonic stem cells.
Stem Cells. 2017;35:2229-2238.
2017 Nov;35(11):2229-2238. doi: 10.1002/stem.2673. Epub 2017 Aug 8.
*Corresponding author.

Kometani M, Yoneda T, Demura M, Koide H, Nishimoto K, Mukai K, Gomez-Sanchez CE, Akagi T, Yokota T, Horike SI, Karashima S, Miyamori I, Yamagishi M, Takeda Y.
Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia.
Sci Rep. 2017;7:11205.
2017 Sep 11;7(1):11205. doi: 10.1038/s41598-017-11435-2.

Xie J, Lin D, Lee DH, Akunowicz J, Hansen M, Miller C, Sanada M, Kato M, Akagi T, Kawamata N, Ogawa S, Koeffler HP.
Copy number analysis identifies tumor suppressive lncRNAs in human osteosarcoma.

Int J Oncol. 2017;50:863-872.
2017 Mar;50(3):863-872. doi: 10.3892/ijo.2017.3864. Epub 2017 Jan 30.

Uranishi K, Akagi T*, Koide H, Yokota T.
Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3.
Biochem Biophys Res Commun. 2016;478:1720-1725.
2016 Sep 30;478(4):1720-5. doi: 10.1016/j.bbrc.2016.09.011. Epub 2016 Sep 4.
*Corresponding author.

Akagi T, Kuure S, Uranishi K, Koide H, Costantini F, Yokota T.
ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in ES cells.
J Biol. Chem. 2015;290:22460-22473.
2015 Sep 11;290(37):22460-73. doi: 10.1074/jbc.M115.675595. Epub 2015 Jul 29.

Wada T#, Akagi T#, Muraoka M, Toma T, Kaji K, Agematsu K, Koeffler HP, Yokota T, Yachie A.
A novel in-frame deletion in the leucine zipper domain of C/EBP-epsilon leads to neutrophil-specific granule deficiency.
J Immunol. 2015;195:80-86.
2015 Jul 1;195(1):80-6. doi: 10.4049/jimmunol.1402222. Epub 2015 May 27.
#Equal contribution.

Kanai D, Ueda A, Akagi T, Yokota T, Koide H.
Oct3/4 directly regulates expression of E2F3a in mouse embryonic stem cells.

Biochem Biophys Res Commun. 2015;459:374-378.
2015 Apr 10;459(3):374-8. doi: 10.1016/j.bbrc.2015.02.105. Epub 2015 Feb 26.

Garg M, Okamoto R, Nagata Y, Kanojia D, Venkatesan S, M T A, Braunstein GD, Said JW, Doan NB, Ho Q, Akagi T, Gery S, Liu LZ, Tan KT, Chng WJ, Yang H, Ogawa S, Koeffler HP.
Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft.
J Clin Endocrinol Metab. 2015;100:725-735.
2015 Feb;100(2):725-35. doi: 10.1210/jc.2014-2359. Epub 2014 Nov 3.

Tada Y, Yamaguchi Y, Kinjo T, Song X, Akagi T, Takamura H, Ohta T, Yokota T, Koide H.
The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells.
Oncogene. 2015;34:752-760.
2015 Feb 5;34(6):752-60. doi: 10.1038/onc.2013.599. Epub 2014 Jan 27.

Nowak D, Liem NL, Mossner M, Klaumünzer M, Papa RA, Nowak V, Jann JC, Akagi T, Kawamata N, Okamoto R, Thoennissen NH, Kato M, Sanada M, Hofmann WK, Ogawa S, Marshall GM, Lock RB, Koeffler HP.
Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.
Exp Hematol. 2015;43:32-43.
2015 Jan;43(1):32-43.e1-35. doi: 10.1016/j.exphem.2014.09.007. Epub 2014 Oct 29.

Hakim F, Kaitsuka T, Raeed JM, Wei FY, Shiraki N, Akagi T, Yokota T, Kume S, Tomizawa K.
High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells.

J Biol. Chem. 2014;289:9623-9638.
2014 Apr 4;289(14):9623-38. doi: 10.1074/jbc.M113.524363. Epub 2014 Feb 19.

Yamaguchi Y, Takamura H, Tada Y, Akagi T, Oyama K, Miyashita T, Tajima H, Kitagawa H, Fushida S, Yokota T, Ohta T, Koide H.
Nanog positively regulates Zfp57 expression in mouse embryonic stem cells.

Biochem Biophys Res Commun. 2014;453:817-820.
2014 Oct 31;453(4):817-20. doi: 10.1016/j.bbrc.2014.10.020. Epub 2014 Oct 14.

Okamoto R, Gery S, Gombart AF, Wang X, Castellani LW, Akagi T, Chen S, Arditi M, Ho Q, Lusis AJ, Li Q, Koeffler HP.
Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice.
PLoS One. 2014;9:e85341.
2014 Jan 28;9(1):e85341. doi: 10.1371/journal.pone.0085341. eCollection 2014.

Okamoto R, Sigal G, Kuwayama Y, Borregaard N, Ho Q, Alvarez R, Akagi T, Liu GY, Uskokovic MR, Koeffler HP.
Novel Gemini vitamin D3 analogs: large structure/function analysis and ability to induce antimicrobial peptide.
Int J Cancer. 2014;134:207-217.
2014 Jan 1;134(1):207-17. doi: 10.1002/ijc.28328. Epub 2013 Jul 16.

Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y.
Dynamic CCAAT/enhancer binding protein (CEBP)-associated changes of DNA methylation in the angiotensinogen gene.
Hypertension. 2014;63:281-288.
2014 Feb;63(2):281-8. doi: 10.1161/HYPERTENSIONAHA.113.02303. Epub 2013 Nov 4.

Fujii Y, Kakegawa M, Koide H, Akagi T*, Yokota T.
Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator.
Biochem Biophys Res Commun. 2013;441:411-417.
2013 Nov 15;441(2):411-7. doi: 10.1016/j.bbrc.2013.10.073. Epub 2013 Oct 22
*Corresponding author.

Uranishi K, Akagi T*, Sun C, Koide H, Yokota T.
Dax1 associates with Esrrb and regulates its function in embryonic stem cells.

Mol Cell Biol. 2013 May;33(10):2056-66. doi: 10.1128/MCB.01520-12. Epub 2013 Mar 18.
*Corresponding author.

Okamoto R, Delansorne R, Wakimoto N, Bodoan N, Akagi T, Shen M, Ho QH, Said J, Koeffler HP.
Inecalcitol, an analog of 1α,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cells.
Int J Cancer. 2012;130:2464-2473.
May 15;130(10):2464-73. doi: 10.1002/ijc.26279. Epub 2011 Aug 27.

Ura H, Murakami K, Akagi T, Kinoshita K, Yamaguchi S, Masui S, Niwa H, Koide H, Yokota T.
Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation.
EMBO J. 2011;30:2190-2204.
2011 Jun 1;30(11):2190-204. doi: 10.1038/emboj.2011.126. Epub 2011 May 3.

Akagi T*, Thoennissen NH, George A, Crooks G, Song JH, Okamoto R, Nowak D, Gombart AF, and Koeffler HP.
In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.
PLoS One. 2010;5:e15419.
2010 Nov 3;5(11):e15419. doi: 10.1371/journal.pone.0015419.

Okamoto R, Ogawa S, Nowak D, Kawamata N, Akagi T, Kato M, Sanada M, Weiss T, Haferlach C, Dugas M, Ruckert C, Haferlach T, Koeffler HP.
Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia.
Haematologica. 2010;95:1481-1488.
2010 Sep;95(9):1481-8. doi: 10.3324/haematol.2009.011114. Epub 2010 Apr 30.

Akagi T*, Ito T, Kato M, Jin Z, Cheng Y, Kan T, Yamamoto G, Olaru A, Kawamata N, Boult J, Soukiasian HJ, Miller CW, Ogawa S, Meltzer SJ, Koeffler HP.
Chromosomal abnormalities and novel disease-related regions in progression from Barrett’s esophagus to esophageal adenocarcinoma.

Int J Cancer. 2009;125:2349-2359.
2009 Nov 15;125(10):2349-59. doi: 10.1002/ijc.24620.

Sun C#, Nakatake Y#, Akagi T#, Ura H#, Matsuda T, Nishiyama A, Koide H, Ko MS, Niwa H, Yokota T.
Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells.
Mol Cell Biol. 2009;29:4574-4583.
2009 Aug;29(16):4574-83. doi: 10.1128/MCB.01863-08. Epub 2009 Jun 15.
#Equal contribution.

Akagi T*, Shih LY, Ogawa S, Gerss J, Moore SR, Schreck R, Kawamata N, Liang DC, Sanada M, Nannya Y, Deneberg S, Zachariadis V, Nordgren A, Song JH, Dugas M, Lehmann S, Koeffler HP.
Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells.
Haematologica. 2009;94:1301-1306.
2009 Sep;94(9):1301-6. doi: 10.3324/haematol.2009.005744.

Nowak D, Toriellec EL, Stern MH, Kawamata N, Akagi T, Dyer MJ, Hofmann WK, Ogawa S, Koeffler HP.
Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy.
Haematologica. 2009;94:518-527.
2009 Apr;94(4):518-27. doi: 10.3324/haematol.2008.001347. Epub 2009 Mar 10.

Akagi T*, Yin D, Kawamata N, Bartram CR, Hofmann WK, Song JH, Miller CW, den Boer ML, Koeffler HP.
Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells.
Leukemia Res. 2009;33:991-996.
2009 Jul;33(7):991-6. doi: 10.1016/j.leukres.2008.10.022. Epub 2008 Dec 2.

Akagi T*, Shih LY, Kato M, Kawamata N, Yamamoto G, Sanada M, Okamoto R, Miller CW, Liang DC, Ogawa S, Koeffler HP.
Hidden abnormalities and novel classification of t(15;17) APL based on genomic alterations.
Blood. 2009;113:1741-1748.
2009 Feb 19;113(8):1741-8. doi: 10.1182/blood-2007-12-130260. Epub 2008 Dec 23.

Akagi T*, Ogawa S, Dugas M, Kawamata N, Yamamoto G, Nannya Y, Sanada M, Miller CW, Yung A, Schnittger S, Haferlach T, Haferlach C, Koeffler HP.
Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype.
Haematologica. 2009;94:213-223.
2009 Feb;94(2):213-23. doi: 10.3324/haematol.13024. Epub 2009 Jan 14.

Kumagai T#, Akagi T#, Desmond JC, Kawamata N, Gery S, Imai Y, Song JH, Gui D, Said J, Koeffler HP.
Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells.
Int J Cancer. 2009;124:827-833.
2009 Feb 15;124(4):827-33. doi: 10.1002/ijc.23994.
#Equal contribution.

Wakimoto N, Wolf I, Yin D, O'Kelly J, Akagi T, Abramovitz L, Black KL, Tai HH, Koeffler HP.
Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase.
Cancer Res. 2008;68:6978-6986.
2008 Sep 1;68(17):6978-86. doi: 10.1158/0008-5472.CAN-07-5675.

Akagi T*, Luong QT, Gui D, Said J, Selektar J, Yung A, Bunce CM, Braunstein GD, Koeffler HP.
Induction of sodium iodide symporter gene and molecular characterisation of HNF3 beta/FoxA2, TTF-1 and C/EBP beta in thyroid carcinoma cells.
Br J Cancer. 2008;99:781-788.
2008 Sep 2;99(5):781-8. doi: 10.1038/sj.bjc.6604544.

Akagi T*, Saitoh T, O'Kelly J, Akira S, Gombart AF, Koeffler HP.
Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells.
Blood. 2008;111:2999-3004*.
2008 Mar 15;111(6):2999-3004. Epub 2007 Dec 4.
(*This manuscript was referred in Comment at the same issue of Blood: Müller-Tidow C and Koschmieder S. The hidden faces of C/EBPβ. Blood. 2008;111:2949-2950.)

Sun C, Nakatake Y, Ura H, Akagi T, Niwa H, Koide H, Yokota T.
Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells.
Biochem Biophys Res Commun. 2008;372:91-96.
2008 Jul 18;372(1):91-6. doi: 10.1016/j.bbrc.2008.04.154. Epub 2008 May 7.

Ura H, Usuda M, Kinoshita K, Sun C, Mori K, Akagi T, Matsuda T, Koide H, Yokota T.
STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells.
J Biol Chem. 2008;283:9713-9723.
2008 Apr 11;283(15):9713-23. doi: 10.1074/jbc.M707275200. Epub 2008 Jan 16.

Kinoshita K, Ura H, Akagi T, Usuda M, Koide H, Yokota T.
GABPalpha regulates Oct-3/4 expression in mouse embryonic stem cells.
Biochem Biophys Res Commun. 2007;353:686-691.
2007 Feb 16;353(3):686-91. Epub 2006 Dec 19.

Akagi T*, Yin D, Kawamata N, Bartram CR, Hofmann WK, Wolf I, Miller CW, Koeffler HP.
Methylation analysis of asparagine synthetase gene in acute lymphoblastic leukemia cells.
Leukemia. 2006;20:1303-1306.
2006 Jul;20(7):1303-6. Epub 2006 Apr 6.

Akagi T, Usuda M, Matsuda T, Ko MS, Niwa H, Asano M, Koide H, Yokota T.
Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells.
Biochem Biophys Res Commun. 2005;331:23-30.
2005 May 27;331(1):23-30.

Kawamura H, Tomozoe Y, Akagi T, Kamei D, Ochiai M, Yamada M.
Identification of the nucleocytoplasmic shuttling sequence of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its interaction with mRNA.
J Biol Chem. 2002;277:2732-2739.
2002 Jan 25;277(4):2732-9. Epub 2001 Nov 8.

Akagi T, Kamei D, Tsuchiya N, Nishina Y, Horiguchi H, Matsui M, Kamma H, Yamada M.
Molecular characterization of a mouse heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its tissue-specific expression.
Gene. 2000;245:267-273.